The Genomics and Drugs integrated Analysis portal (GDA) is a web-based tool that combines NCI60 uniquely large number of drug sensitivity data with CCLE and NCI60 gene mutation and expression profiles. GDA currently contains drug sensitivity data for more than 50,800 compounds, describing response in 115 cancer cell lines characterized by their transcriptional and mutational backgrounds. GDA is composed of 4 main analysis modules that allow identifying i) drugs active in cancer cell lines bearing specific gene mutations (from gene to drug); ii) gene mutations characterizing cancer cell lines that are responsive to a selected compound (from drug to gene); iii) drugs active in cancer cell lines bearing the activation of a specific gene signature (from signature to drug); and iv) up- and down-regulated genes in cancer cell lines that are responsive to a specific compound (from drug to signature).